What kind of significant impacts have originated from $E=m{c}^{2}$.

Generally, it is regarded as the most famous equation of all time. Except for nuclear energy (fission and fusion) I do not know any other way in which this equation has made an impact on the world.

Can somebody list some developments and impacts based on this equation?

Generally, it is regarded as the most famous equation of all time. Except for nuclear energy (fission and fusion) I do not know any other way in which this equation has made an impact on the world.

Can somebody list some developments and impacts based on this equation?