# Two drugs, Abraxane and Taxol, are both cancer treatments, yet have differing rates at which they leave a patient’s system. Using terminology from pharmacology, Abraxane leaves the system by so-called “first-order elimination”, which means that the concentration decreases at a constant percentage rate for each unit of time that passes. Taxol leaves the system by “zero-order elimination”, which means that the concentration decreases by a constant amount for each unit of time that passes. (a) As soon as the infusion of Taxol is completed, the drug concentration in a patient’s blood is 1000 nanograms per milliliter displaystyle{left(frac{{{n}{g}}}{{{m}{l}}}right)}. 12 hours later there is displaystyle{50}frac{{{n}{g}}}{{{m}{l}}} left in the patient’s system. Use the data to construct an appr

Question
Modeling data distributions
Two drugs, Abraxane and Taxol, are both cancer treatments, yet have differing rates at which they leave a patient’s system. Using terminology from pharmacology, Abraxane leaves the system by so-called “first-order elimination”, which means that the concentration decreases at a constant percentage rate for each unit of time that passes. Taxol leaves the system by “zero-order elimination”, which means that the concentration decreases by a constant amount for each unit of time that passes.
(a) As soon as the infusion of Taxol is completed, the drug concentration in a patient’s blood is 1000 nanograms per milliliter $$\displaystyle{\left(\frac{{{n}{g}}}{{{m}{l}}}\right)}.$$ 12 hours later there is $$\displaystyle{50}\frac{{{n}{g}}}{{{m}{l}}}$$ left in the patient’s system. Use the data to construct an appropriate formula modeling the blood concentration of Taxol as a function of time after the infusion is completed.
(b) As soon as the infusion of Abraxane is completed, the drug concentration in a patient’s blood is 1000 nanograms per milliliter $$\displaystyle{\left(\frac{{{n}{g}}}{{{m}{l}}}\right)}$$. 24 hours later there is $$\displaystyle{50}\frac{{{n}{g}}}{{{m}{l}}}$$ left in the patient’s system. Use the data to construct an appropriate formula modeling the blood concentration of Abraxane as a function of time after the infusion is completed.
(c) Find the long-term behavior of the function from part (b). Is this behavior meaningful in the context of the model?

2020-11-27

(a)
Let T(t)−Amount of taxol in nanogram per mili litre present in the patient's blood at any time t in (hours) since infusion completely [Infusion completes at $$\displaystyle{t}={0}$$] As T(t) taxol follow zero order elimination.
$$\displaystyle{T}{\left({t}\right)}={m}{\left({t}\right)}+{c},$$ where m is a slope
at $$\displaystyle{t}={0}\Rightarrow{T}{\left({t}\right)}={1000}\to{c}={1000}$$
and $$\displaystyle{a}{t}{t}={12}\Rightarrow{T}{\left({12}\right)}={100}$$
$$\displaystyle{50}={m}\times{12}+{1000}$$
$$\displaystyle\Rightarrow{m}=-{79.16}$$
Hence, $$\displaystyle{T}{\left({t}\right)}=-{79.16}{t}+{1000}$$
(b)
$$A(t)$$to Amount of Abraxane in ng/ml in patient's bloodat any time t in (hours) since infusion. As Abrasane follows Istorder elimination.
$$\displaystyle{A}{\left({t}\right)}={P}{\left(\theta\right)}^{t}$$
at $$\displaystyle{t}={0},{A}{\left({t}\right)}={1000}\Rightarrow{1000}={P}{\left(\theta\right)}^{0}\to{P}={1000}$$
Now,
$$\displaystyle{A}{\left({t}\right)}={1000}{\left(\theta\right)}^{t}At t = 24, A(t) = 50$$
$$\displaystyle{50}={1000}{\left(\theta\right)}^{24}$$
$$\displaystyle\theta={\left(\frac{1}{{20}}\right)}^{{\frac{1}{{24}}}}\Rightarrow\theta={0.88265}$$
Hence, $$\displaystyle{A}{\left({t}\right)}={1000}{\left({0.8826}\right)}^{t}$$
(c)
From the part (b): $$\displaystyle{A}{\left({t}\right)}={1000}{\left({0.8826}\right)}^{t}\ldots\ldots{\left({1}\right)}$$
where,
$$\displaystyle{A}{\left({t}\right)}=$$ Amount of Abraxane in the patient's blood.
The equation (1) shows that the amount of Abraxane inpatient'sblood is exponentially decreasing in the patient'sblood.

### Relevant Questions

The dominant form of drag experienced by vehicles (bikes, cars,planes, etc.) at operating speeds is called form drag. Itincreases quadratically with velocity (essentially because theamount of air you run into increase with v and so does the amount of force you must exert on each small volume of air). Thus
$$\displaystyle{F}_{{{d}{r}{u}{g}}}={C}_{{d}}{A}{v}^{{2}}$$
where A is the cross-sectional area of the vehicle and $$\displaystyle{C}_{{d}}$$ is called the coefficient of drag.
Part A:
Consider a vehicle moving with constant velocity $$\displaystyle\vec{{{v}}}$$. Find the power dissipated by form drag.
Express your answer in terms of $$\displaystyle{C}_{{d}},{A},$$ and speed v.
Part B:
A certain car has an engine that provides a maximum power $$\displaystyle{P}_{{0}}$$. Suppose that the maximum speed of thee car, $$\displaystyle{v}_{{0}}$$, is limited by a drag force proportional to the square of the speed (as in the previous part). The car engine is now modified, so that the new power $$\displaystyle{P}_{{1}}$$ is 10 percent greater than the original power ($$\displaystyle{P}_{{1}}={110}\%{P}_{{0}}$$).
Assume the following:
The top speed is limited by air drag.
The magnitude of the force of air drag at these speeds is proportional to the square of the speed.
By what percentage, $$\displaystyle{\frac{{{v}_{{1}}-{v}_{{0}}}}{{{v}_{{0}}}}}$$, is the top speed of the car increased?
Express the percent increase in top speed numerically to two significant figures.
The unstable nucleus uranium-236 can be regarded as auniformly charged sphere of charge Q=+92e and radius $$\displaystyle{R}={7.4}\times{10}^{{-{15}}}$$ m. In nuclear fission, this can divide into twosmaller nuclei, each of 1/2 the charge and 1/2 the voume of theoriginal uranium-236 nucleus. This is one of the reactionsthat occurred n the nuclear weapon that exploded over Hiroshima, Japan in August 1945.
A. Find the radii of the two "daughter" nuclei of charge+46e.
B. In a simple model for the fission process, immediatelyafter the uranium-236 nucleus has undergone fission the "daughter"nuclei are at rest and just touching. Calculate the kineticenergy that each of the "daughter" nuclei will have when they arevery far apart.
C. In this model the sum of the kinetic energies of the two"daughter" nuclei is the energy released by the fission of oneuranium-236 nucleus. Calculate the energy released by thefission of 10.0 kg of uranium-236. The atomic mass ofuranium-236 is 236 u, where 1 u = 1 atomic mass unit $$\displaystyle={1.66}\times{10}^{{-{27}}}$$ kg. Express your answer both in joules and in kilotonsof TNT (1 kiloton of TNT releases 4.18 x 10^12 J when itexplodes).
Consider the curves in the first quadrant that have equationsy=Aexp(7x), where A is a positive constant. Different valuesof A give different curves. The curves form a family,F. Let P=(6,6). Let C be the number of the family Fthat goes through P.
A. Let y=f(x) be the equation of C. Find f(x).
B. Find the slope at P of the tangent to C.
C. A curve D is a perpendicular to C at P. What is the slope of thetangent to D at the point P?
D. Give a formula g(y) for the slope at (x,y) of the member of Fthat goes through (x,y). The formula should not involve A orx.
E. A curve which at each of its points is perpendicular to themember of the family F that goes through that point is called anorthogonal trajectory of F. Each orthogonal trajectory to Fsatisfies the differential equation dy/dx = -1/g(y), where g(y) isthe answer to part D.
Find a function of h(y) such that x=h(y) is the equation of theorthogonal trajectory to F that passes through the point P.
An automobile tire manufacturer collected the data in the table relating tire pressure x​ (in pounds per square​ inch) and mileage​ (in thousands of​ miles). A mathematical model for the data is given by
$$\displaystyle​ f{{\left({x}\right)}}=-{0.554}{x}^{2}+{35.5}{x}-{514}.$$
$$\begin{array}{|c|c|} \hline x & Mileage \\ \hline 28 & 45 \\ \hline 30 & 51\\ \hline 32 & 56\\ \hline 34 & 50\\ \hline 36 & 46\\ \hline \end{array}$$
​(A) Complete the table below.
$$\begin{array}{|c|c|} \hline x & Mileage & f(x) \\ \hline 28 & 45 \\ \hline 30 & 51\\ \hline 32 & 56\\ \hline 34 & 50\\ \hline 36 & 46\\ \hline \end{array}$$
​(Round to one decimal place as​ needed.)
$$A. 20602060xf(x)$$
A coordinate system has a horizontal x-axis labeled from 20 to 60 in increments of 2 and a vertical y-axis labeled from 20 to 60 in increments of 2. Data points are plotted at (28,45), (30,51), (32,56), (34,50), and (36,46). A parabola opens downward and passes through the points (28,45.7), (30,52.4), (32,54.7), (34,52.6), and (36,46.0). All points are approximate.
$$B. 20602060xf(x)$$
Acoordinate system has a horizontal x-axis labeled from 20 to 60 in increments of 2 and a vertical y-axis labeled from 20 to 60 in increments of 2.
Data points are plotted at (43,30), (45,36), (47,41), (49,35), and (51,31). A parabola opens downward and passes through the points (43,30.7), (45,37.4), (47,39.7), (49,37.6), and (51,31). All points are approximate.
$$C. 20602060xf(x)$$
A coordinate system has a horizontal x-axis labeled from 20 to 60 in increments of 2 and a vertical y-axis labeled from 20 to 60 in increments of 2. Data points are plotted at (43,45), (45,51), (47,56), (49,50), and (51,46). A parabola opens downward and passes through the points (43,45.7), (45,52.4), (47,54.7), (49,52.6), and (51,46.0). All points are approximate.
$$D.20602060xf(x)$$
A coordinate system has a horizontal x-axis labeled from 20 to 60 in increments of 2 and a vertical y-axis labeled from 20 to 60 in increments of 2. Data points are plotted at (28,30), (30,36), (32,41), (34,35), and (36,31). A parabola opens downward and passes through the points (28,30.7), (30,37.4), (32,39.7), (34,37.6), and (36,31). All points are approximate.
​(C) Use the modeling function​ f(x) to estimate the mileage for a tire pressure of 29
$$\displaystyle​\frac{{{l}{b}{s}}}{{{s}{q}}}\in.$$ and for 35
$$\displaystyle​\frac{{{l}{b}{s}}}{{{s}{q}}}\in.$$
The mileage for the tire pressure $$\displaystyle{29}\frac{{{l}{b}{s}}}{{{s}{q}}}\in.$$ is
The mileage for the tire pressure $$\displaystyle{35}\frac{{{l}{b}{s}}}{{{s}{q}}}$$ in. is
(Round to two decimal places as​ needed.)
(D) Write a brief description of the relationship between tire pressure and mileage.
A. As tire pressure​ increases, mileage decreases to a minimum at a certain tire​ pressure, then begins to increase.
B. As tire pressure​ increases, mileage decreases.
C. As tire pressure​ increases, mileage increases to a maximum at a certain tire​ pressure, then begins to decrease.
D. As tire pressure​ increases, mileage increases.
An airplane propeller is 2.08 m in length (from tip to tip) and has a mass of 117 kg. When the airpline's engine is first started, it applies a constant torque of $$\displaystyle{1950}\ {N}\cdot{m}$$ to the propeller, which starts from rest.
a) What is the angular acceleration of the propeller? Model the propeller as a slender rod.
b) What is the propeller's angular speed after making 5.00 revolutions?
c) How much work is done by the engine during the first 5.00 revolutions?
e) What is the instantaneous power output of the motor at the instant that the propeller has turne through 5.00 revolutions?
4.7 A multiprocessor with eight processors has 20attached tape drives. There is a large number of jobs submitted tothe system that each require a maximum of four tape drives tocomplete execution. Assume that each job starts running with onlythree tape drives for a long period before requiring the fourthtape drive for a short period toward the end of its operation. Alsoassume an endless supply of such jobs.
a) Assume the scheduler in the OS will not start a job unlessthere are four tape drives available. When a job is started, fourdrives are assigned immediately and are not released until the jobfinishes. What is the maximum number of jobs that can be inprogress at once? What is the maximum and minimum number of tapedrives that may be left idle as a result of this policy?
b) Suggest an alternative policy to improve tape driveutilization and at the same time avoid system deadlock. What is themaximum number of jobs that can be in progress at once? What arethe bounds on the number of idling tape drives?
Aurora is planning to participate in an event at her school's field day that requires her to complete tasks at various stations in the fastest time possible. To prepare for the event, she is practicing and keeping track of her time to complete each station. The x-coordinate is the station number, and the y-coordinate is the time in minutes since the start of the race that she completed the task. $$\displaystyle{\left({1},{3}\right)},{\left({2},{6}\right)},{\left({3},{12}\right)},{\left({4},{24}\right)}$$
Part A: Is this data modeling an algebraic sequence or a geometric sequence? Explain your answer.
Part B: Use a recursive formula to determine the time she will complete station 5.
Part C: Use an explicit formula to find the time she will complete the 9th station.
1. Find each of the requested values for a population with a mean of $$? = 40$$, and a standard deviation of $$? = 8$$ A. What is the z-score corresponding to $$X = 52?$$ B. What is the X value corresponding to $$z = - 0.50?$$ C. If all of the scores in the population are transformed into z-scores, what will be the values for the mean and standard deviation for the complete set of z-scores? D. What is the z-score corresponding to a sample mean of $$M=42$$ for a sample of $$n = 4$$ scores? E. What is the z-scores corresponding to a sample mean of $$M= 42$$ for a sample of $$n = 6$$ scores? 2. True or false: a. All normal distributions are symmetrical b. All normal distributions have a mean of 1.0 c. All normal distributions have a standard deviation of 1.0 d. The total area under the curve of all normal distributions is equal to 1 3. Interpret the location, direction, and distance (near or far) of the following zscores: $$a. -2.00 b. 1.25 c. 3.50 d. -0.34$$ 4. You are part of a trivia team and have tracked your team’s performance since you started playing, so you know that your scores are normally distributed with $$\mu = 78$$ and $$\sigma = 12$$. Recently, a new person joined the team, and you think the scores have gotten better. Use hypothesis testing to see if the average score has improved based on the following 8 weeks’ worth of score data: $$82, 74, 62, 68, 79, 94, 90, 81, 80$$. 5. You get hired as a server at a local restaurant, and the manager tells you that servers’ tips are $42 on average but vary about $$12 (\mu = 42, \sigma = 12)$$. You decide to track your tips to see if you make a different amount, but because this is your first job as a server, you don’t know if you will make more or less in tips. After working 16 shifts, you find that your average nightly amount is$44.50 from tips. Test for a difference between this value and the population mean at the $$\alpha = 0.05$$ level of significance.
The table below shows the number of people for three different race groups who were shot by police that were either armed or unarmed. These values are very close to the exact numbers. They have been changed slightly for each student to get a unique problem.
Suspect was Armed:
Black - 543
White - 1176
Hispanic - 378
Total - 2097
Suspect was unarmed:
Black - 60
White - 67
Hispanic - 38
Total - 165
Total:
Black - 603
White - 1243
Hispanic - 416
Total - 2262
Give your answer as a decimal to at least three decimal places.
a) What percent are Black?
b) What percent are Unarmed?
c) In order for two variables to be Independent of each other, the P $$(A and B) = P(A) \cdot P(B) P(A and B) = P(A) \cdot P(B).$$
This just means that the percentage of times that both things happen equals the individual percentages multiplied together (Only if they are Independent of each other).
Therefore, if a person's race is independent of whether they were killed being unarmed then the percentage of black people that are killed while being unarmed should equal the percentage of blacks times the percentage of Unarmed. Let's check this. Multiply your answer to part a (percentage of blacks) by your answer to part b (percentage of unarmed).
Remember, the previous answer is only correct if the variables are Independent.
d) Now let's get the real percent that are Black and Unarmed by using the table?
If answer c is "significantly different" than answer d, then that means that there could be a different percentage of unarmed people being shot based on race. We will check this out later in the course.
Let's compare the percentage of unarmed shot for each race.
e) What percent are White and Unarmed?
f) What percent are Hispanic and Unarmed?
If you compare answers d, e and f it shows the highest percentage of unarmed people being shot is most likely white.
Why is that?
This is because there are more white people in the United States than any other race and therefore there are likely to be more white people in the table. Since there are more white people in the table, there most likely would be more white and unarmed people shot by police than any other race. This pulls the percentage of white and unarmed up. In addition, there most likely would be more white and armed shot by police. All the percentages for white people would be higher, because there are more white people. For example, the table contains very few Hispanic people, and the percentage of people in the table that were Hispanic and unarmed is the lowest percentage.
Think of it this way. If you went to a college that was 90% female and 10% male, then females would most likely have the highest percentage of A grades. They would also most likely have the highest percentage of B, C, D and F grades
The correct way to compare is "conditional probability". Conditional probability is getting the probability of something happening, given we are dealing with just the people in a particular group.
g) What percent of blacks shot and killed by police were unarmed?
h) What percent of whites shot and killed by police were unarmed?
i) What percent of Hispanics shot and killed by police were unarmed?
You can see by the answers to part g and h, that the percentage of blacks that were unarmed and killed by police is approximately twice that of whites that were unarmed and killed by police.
j) Why do you believe this is happening?
Do a search on the internet for reasons why blacks are more likely to be killed by police. Read a few articles on the topic. Write your response using the articles as references. Give the websites used in your response. Your answer should be several sentences long with at least one website listed. This part of this problem will be graded after the due date.